These are some disadvantages of using paper chromatography:
1. It can be used as a preparative technique because we can't aplly a large sample quantity;
2. It can't be used in quantitative analysis;
3. and doesn't allow the separation of complex mixtures.
4.this is one of oldest method
These are some advantages of using paper chromatography:
It's less expensive to perform, and you can do "two way" chromatography by running a chromatograph in one solvent, letting the paper dry, turning it 90 degrees and running a second chromatograph in a different solvent.
Thin layer chromatography is faster and more accurate, so it's more popular now.
HELMI (27)